厦门市仙岳医院使用IPHASE产品发表高质量文章（IF=4.2）

近日，厦门市仙岳医院刘珂珺老师，使用IPHASE品牌产品：NADPH Regeneration System 在《Results in Chemistry》权威期刊上发表文章《Herb-drug interaction between Dahuang-Gancao decoction and clozapine:A pharmacokinetic study in rats》，影响因子4.2！

 

【摘要】

Dahuang-Gancao decoction (DGD) comprises Rhei Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma at ratio of 4:1, which is usually applied for relieving clozapine-induced constipation in clinical practice. However, the herb-drug interactions involving antipsychotics with narrow therapeutic range have rarely been reported. We investigated a potential pharmacokinetic-based interaction between DGD and clozapine based on in vitro and in vivo studies. Rats received a single injection of clozapine (5 mg/kg, i.v.,) 30 min after pretreatment with DGD (p. o.) for 3 days or 14 days. The concentrations of clozapine and its metabolites in rat plasma were measured by high-performance liquid chromatography-tandem mass spectrometry. The effects of DGD on protein expression of cytochrome P450 (CYP450) in vivo and the binding of plasma proteins to clozapine in vitro were determined. After 3-day pretreatment with DGD, there were no significant changes in the pharmacokinetics of clozapine or its metabolites. A significant incr

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